[HTML][HTML] Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism
D Beitner-Johnson, DE Millhorn - Journal of Biological Chemistry, 1998 - ASBMB
To investigate signaling mechanisms by which hypoxia regulates gene expression, we
examined the effect of hypoxia on the cyclic AMP response element-binding protein (CREB)
in PC12 cells. Exposure to physiological levels of hypoxia (5% O 2,∼ 50 mm Hg) rapidly
induced a persistent phosphorylation of CREB on Ser 133, an event that is required for
CREB-mediated transcriptional activation. Hypoxia-induced phosphorylation of CREB was
more robust than that induced by any other stimulus tested, including forskolin …
examined the effect of hypoxia on the cyclic AMP response element-binding protein (CREB)
in PC12 cells. Exposure to physiological levels of hypoxia (5% O 2,∼ 50 mm Hg) rapidly
induced a persistent phosphorylation of CREB on Ser 133, an event that is required for
CREB-mediated transcriptional activation. Hypoxia-induced phosphorylation of CREB was
more robust than that induced by any other stimulus tested, including forskolin …