Recognition of trophoblast HLA class I molecules by decidual NK cell receptors—a review
A King, SE Hiby, L Gardner, S Joseph, JM Bowen… - Placenta, 2000 - Elsevier
During placentation the extravillous trophoblast (EVT) cells migrate through the decidua
towards the maternal spiral arteries. The walls of the arteries are then destroyed by
trophoblast resulting in an increased blood flow to the fetus. These EVT express HLA-G,
HLA-E and HLA-C, an unusual combination of two non-classical and one classical MHC
class I molecules. The decidua is infiltrated by distinctive uterine natural killer (NK) cells
during the time of trophoblast invasion. These cells express a variety of receptors …
towards the maternal spiral arteries. The walls of the arteries are then destroyed by
trophoblast resulting in an increased blood flow to the fetus. These EVT express HLA-G,
HLA-E and HLA-C, an unusual combination of two non-classical and one classical MHC
class I molecules. The decidua is infiltrated by distinctive uterine natural killer (NK) cells
during the time of trophoblast invasion. These cells express a variety of receptors …