Homotypic and heterotypic Ca++-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell …
S Oikawa, M Kuroki, Y Matsuoka, G Kosaki… - Biochemical and …, 1992 - Elsevier
S Oikawa, M Kuroki, Y Matsuoka, G Kosaki, H Nakazato
Biochemical and biophysical research communications, 1992•ElsevierHomotypic and heterotypic cell adhesion activities of a carcinoembryonic antigen (CEA)
family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected
with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have
been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA
and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was
not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the …
family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected
with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have
been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA
and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was
not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the …
Abstract
Homotypic and heterotypic cell adhesion activities of a carcinoembryonic antigen (CEA) family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the adhesions of other members of CEA family. The results strongly suggested that BGPa may play some important roles through Ca++-independent cell adhesion activities.
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