Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer.
K Inoue, Y Kawahito, Y Tsubouchi, R Yamada… - Anticancer …, 2001 - europepmc.org
K Inoue, Y Kawahito, Y Tsubouchi, R Yamada, M Kohno, Y Hosokawa, D Katoh…
Anticancer Research, 2001•europepmc.orgThe peroxisome proliferator-activated receptor (PPAR)-gamma is a member of the steroid
nuclear receptors. Recent studies have demonstrated that PPAR-gamma is expressed in
several cancer cells. We examined the PPAR-gamma expression in both normal lung and
major types of human lung cancer. The expression of PPAR-gamma mRNA was detected in
2 out of 3 normal lung tissues and its protein was detected in 3 out of 5 normal lung tissues.
In contrast, a small cell carcinoma cell line and all other types of lung cancer tissues …
nuclear receptors. Recent studies have demonstrated that PPAR-gamma is expressed in
several cancer cells. We examined the PPAR-gamma expression in both normal lung and
major types of human lung cancer. The expression of PPAR-gamma mRNA was detected in
2 out of 3 normal lung tissues and its protein was detected in 3 out of 5 normal lung tissues.
In contrast, a small cell carcinoma cell line and all other types of lung cancer tissues …
The peroxisome proliferator-activated receptor (PPAR)-gamma is a member of the steroid nuclear receptors. Recent studies have demonstrated that PPAR-gamma is expressed in several cancer cells. We examined the PPAR-gamma expression in both normal lung and major types of human lung cancer. The expression of PPAR-gamma mRNA was detected in 2 out of 3 normal lung tissues and its protein was detected in 3 out of 5 normal lung tissues. In contrast, a small cell carcinoma cell line and all other types of lung cancer tissues expressed PPAR-gamma mRNA and its protein. Immunoreactive PPAR-gamma is strongly expressed in cancer cells and moderately in mononuclear cells, endothelial cells and fibroblasts of lung cancer tissues. Our results suggest that PPAR-gamma may play an important role in the pathogenesis and/or progression of lung cancer, and may be a novel therapeutical target for therapy of lung cancer.
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