[HTML][HTML] PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth
ED Rosen, BM Spiegelman - Journal of Biological Chemistry, 2001 - ASBMB
The peroxisome proliferator-activated receptors (PPARs) 1 comprise an important subfamily
of the nuclear hormone receptor (NHR) superfamily. These ligand-activated transcription
factors have been intensively studied for more than a decade and have been implicated in
such diverse pathways as lipid and glucose homeostasis, control of cellular proliferation,
and differentiation. The name PPAR derives from the initial cloning of one isoform as a target
of various xenobiotic compounds that were observed to induce proliferation of peroxisomes …
of the nuclear hormone receptor (NHR) superfamily. These ligand-activated transcription
factors have been intensively studied for more than a decade and have been implicated in
such diverse pathways as lipid and glucose homeostasis, control of cellular proliferation,
and differentiation. The name PPAR derives from the initial cloning of one isoform as a target
of various xenobiotic compounds that were observed to induce proliferation of peroxisomes …