Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and …
D Marx, M Tassabehji, S Heer, KB Hüttenbrink… - Pulmonary …, 2002 - Elsevier
The aim of this study was to investigate the role of the inhibitors of different PDE isoenzymes
(PDE 1–5) on the production of two pro-inflammatory cytokines–tumor necrosis factor alpha
(TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Two in vitro models
were used to compare the antiinflammatory properties of PDE inhibitors with that of
glucocorticoids. The effect on TNF release from diluted human blood following
lipopolysaccharide (LPS from Salmonella abortus equi) stimulation as well as the GM-CSF …
(PDE 1–5) on the production of two pro-inflammatory cytokines–tumor necrosis factor alpha
(TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Two in vitro models
were used to compare the antiinflammatory properties of PDE inhibitors with that of
glucocorticoids. The effect on TNF release from diluted human blood following
lipopolysaccharide (LPS from Salmonella abortus equi) stimulation as well as the GM-CSF …