Chemokines are thought to play a pivotal role in mediating the selective migration of
leukocytes into sites of tissue injury. The local production of chemokines by mesangial cells
(MC) has been linked to inflammatory processes within the glomerulus. To study the
chemokine biology of human MC, an immortalized human MC line was generated and then
chemokine and chemokine receptor expression was examined in response to various
proinflammatory stimuli. The results show that human MC have a specific and limited …