Tumor necrosis factor α-converting enzyme
RA Black - Handbook of Proteolytic Enzymes, 2004 - Elsevier
Publisher Summary This chapter covers the structural chemistry and the biological aspects
of tumor necrosis factor α-converting enzyme (TACE). This enzyme is called the tumor
necrosis factor α-converting enzyme because it was identified by its ability to cleave 26 kDa
Tumor Necrosis Factor α (TNFα) at the physiological processing site. In vivo, this cleavage
releases the soluble, 17 kDa form of TNFα, which induces inflammation. A concerted effort
was, therefore, made to find the responsible enzyme, using recombinant 26 kDa TNFα as a …
of tumor necrosis factor α-converting enzyme (TACE). This enzyme is called the tumor
necrosis factor α-converting enzyme because it was identified by its ability to cleave 26 kDa
Tumor Necrosis Factor α (TNFα) at the physiological processing site. In vivo, this cleavage
releases the soluble, 17 kDa form of TNFα, which induces inflammation. A concerted effort
was, therefore, made to find the responsible enzyme, using recombinant 26 kDa TNFα as a …