Differential regulation of TNFα, IL-1β, IL-6, IL-8, TNFβ, and IL-10 by pentoxifylline
CL d'Hellencourt, L Diaw, P Cornillet… - International journal of …, 1996 - Elsevier
Pentoxifylline (PTX) is a methylxanthine drug known to inhibit the production of tumor
necrosis factor-alpha (TNFα), which plays a key role in inflammation. Recent studies also
revealed that other cytokines may be inhibited by PTX. We investigated PTX effects on
production and mRNA expression of TNFα, IL-1β, IL-6, IL-8, TNFβ and IL-10. Cytokine
release was studied in 1/10 diluted whole blood culture (WB) and in peripheral blood
mononuclear cell (PBMC) culture. Cytokine production was triggered in both culture systems …
necrosis factor-alpha (TNFα), which plays a key role in inflammation. Recent studies also
revealed that other cytokines may be inhibited by PTX. We investigated PTX effects on
production and mRNA expression of TNFα, IL-1β, IL-6, IL-8, TNFβ and IL-10. Cytokine
release was studied in 1/10 diluted whole blood culture (WB) and in peripheral blood
mononuclear cell (PBMC) culture. Cytokine production was triggered in both culture systems …