Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model
J Villar, SP Ribeiro, JBM Mullen… - Critical care …, 1994 - journals.lww.com
Objective: To test the hypothesis that induction of heat shock proteins before the onset of
sepsis could prevent or reduce organ injury and death in a rat model of intra-abdominal
sepsis and sepsis-induced acute lung injury produced by cecal ligation and perforation.
Design: Prospective, blind, randomized, controlled trial. Setting: University research
laboratory. Subjects: One-hundred forty-two adult Sprague-Dawley rats (weight range 200 to
300 g). Interventions: Production of intra-abdominal sepsis and exposure to heat stress …
sepsis could prevent or reduce organ injury and death in a rat model of intra-abdominal
sepsis and sepsis-induced acute lung injury produced by cecal ligation and perforation.
Design: Prospective, blind, randomized, controlled trial. Setting: University research
laboratory. Subjects: One-hundred forty-two adult Sprague-Dawley rats (weight range 200 to
300 g). Interventions: Production of intra-abdominal sepsis and exposure to heat stress …