Genes involved in initial steps of bile acid synthesis
I Björkhem, G Eggertsen - Current opinion in lipidology, 2001 - journals.lww.com
I Björkhem, G Eggertsen
Current opinion in lipidology, 2001•journals.lww.comThe mechanism and regulation of the degradation of cholesterol into bile acids has attracted
increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X
receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently,
it has also been shown that the biosynthesis of bile acids is not exclusively restricted to the
liver, and that degradation may start by a hydroxylation of cholesterol in the brain or in other
extrahepatic organs. During the past 2 years the genes coding for three of the six enzymes …
increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X
receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently,
it has also been shown that the biosynthesis of bile acids is not exclusively restricted to the
liver, and that degradation may start by a hydroxylation of cholesterol in the brain or in other
extrahepatic organs. During the past 2 years the genes coding for three of the six enzymes …
Abstract
The mechanism and regulation of the degradation of cholesterol into bile acids has attracted increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently, it has also been shown that the biosynthesis of bile acids is not exclusively restricted to the liver, and that degradation may start by a hydroxylation of cholesterol in the brain or in other extrahepatic organs. During the past 2 years the genes coding for three of the six enzymes catalysing the first steps in bile acid biosynthesis have been cloned and characterized. These genes and their gene products will be described here.
Lippincott Williams & Wilkins