[HTML][HTML] Importance of a novel oxidative mechanism for elimination of Brain cholesterol: turnover of cholesterol and 24 (s)-hydroxycholesterol in rat brain as measured …

I Björkhem, D Lütjohann, O Breuer, A Sakinis… - Journal of Biological …, 1997 - ASBMB
The brain is the most cholesterol-rich organ in the body. Brain cholesterol is characterized
by a very low turnover with very little exchange with lipoproteins in the circulation. Very
recently we showed that there is a continuous age-dependent flux of 24 (S)-
hydroxycholesterol from the human brain into the circulation (Lütjohann, D., Breuer, O.,
Ahlborg, G., Nennesmo, I., Sidén, Å., Diczfalusy, U., and Björkhem, I.(1996) Proc. Natl.
Acad. Sci. USA 93, 9799–9804). Here we measured the rate of synthesis of cholesterol as …