The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities
T Maurice, A Urani, VL Phan, P Romieu - Brain Research Reviews, 2001 - Elsevier
Steroids, synthesized in peripheral glands or centrally in the brain—the latter being named
neurosteroids—exert an important role as modulators of the neuronal activity by interacting
with different receptors or ion channels. In addition to the modulation of GABAA, NMDA or
cholinergic receptors, neuroactive steroids interact with an atypical intracellular receptor, the
σ1 protein. This receptor has been cloned in several species, and highly selective synthetic
ligands are available. At the cellular level, σ1 agonists modulate intracellular calcium …
neurosteroids—exert an important role as modulators of the neuronal activity by interacting
with different receptors or ion channels. In addition to the modulation of GABAA, NMDA or
cholinergic receptors, neuroactive steroids interact with an atypical intracellular receptor, the
σ1 protein. This receptor has been cloned in several species, and highly selective synthetic
ligands are available. At the cellular level, σ1 agonists modulate intracellular calcium …