Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis.

G Salen, V Shore, GS Tint, T Forte, S Shefer… - Journal of lipid …, 1989 - ASBMB
We measured the turnover and absorption of sitosterol and cholesterol, along with plasma
sterol and lipoprotein concentrations, in one control and two subjects with sitosterolemia
with xanthomatosis. All individuals consumed the same diet which contained approximately
500 mg/day of cholesterol and 250 mg/day of sitosterol. Sterol absorption was measured by
the plasma dual-isotope ratio method and turnover by plasma isotope-kinetic analysis. In
two sitosterolemic subjects, 28% and 63% of the sitosterol and 69% and 49% of the …