[HTML][HTML] Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8
K Lu, MH Lee, H Yu, Y Zhou, SA Sandell, G Salen… - Journal of lipid …, 2002 - ASBMB
Mammalian physiological processes can distinguish between dietary cholesterol and non-
cholesterol, retaining very little of the non-cholesterol in their bodies. We have recently
identified two genes, ABCG5 and ABCG8, encoding sterolin-1 and-2 respectively, mutations
of which cause the human disease sitosterolemia. We report here the mouse cDNAs and
genomic organization of Abcg5 and Abcg8. Both genes are arranged in an unusual head-to-
head configuration, and only 140 bases separate their two respective start-transcription …
cholesterol, retaining very little of the non-cholesterol in their bodies. We have recently
identified two genes, ABCG5 and ABCG8, encoding sterolin-1 and-2 respectively, mutations
of which cause the human disease sitosterolemia. We report here the mouse cDNAs and
genomic organization of Abcg5 and Abcg8. Both genes are arranged in an unusual head-to-
head configuration, and only 140 bases separate their two respective start-transcription …