Molecular cloning of human and rat complementary DNA encoding androgen receptors
CS Chang, J Kokontis, S Liao - science, 1988 - science.org
CS Chang, J Kokontis, S Liao
science, 1988•science.orgComplementary DNAs (cDNAs) encoding androgen receptors were obtained from human
testis and rat ventral prostate cDNA libraries. The amino acid sequence deduced from the
nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding
domain that is highly conserved in all steroid receptors. The human cDNA was transcribed
and the RNA product was translated in cell-free systems to yield a 76-kilodalton protein. The
protein was immunoprecipitable by human autoimmune antibodies to the androgen …
testis and rat ventral prostate cDNA libraries. The amino acid sequence deduced from the
nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding
domain that is highly conserved in all steroid receptors. The human cDNA was transcribed
and the RNA product was translated in cell-free systems to yield a 76-kilodalton protein. The
protein was immunoprecipitable by human autoimmune antibodies to the androgen …
Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries. The amino acid sequence deduced from the nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors. The human cDNA was transcribed and the RNA product was translated in cell-free systems to yield a 76-kilodalton protein. The protein was immunoprecipitable by human autoimmune antibodies to the androgen receptor. The protein bound androgens specifically and with high affinity.
AAAS