β-Muricholic acid; potentiometric and cholesterol-dissolving properties

JC Montet, M Parquet, E Sacquet, AM Montet… - … et Biophysica Acta (BBA …, 1987 - Elsevier
Some physicochemical properties of β-niuricholic acid (3α, 6β, 7β-trihydroxyβ-cholanic
acid), a major bile acid biosynthesized by rat liver, were determined and compared to those
of ursodeoxycholic and chenodeoxycholic acids. From potentiometric studies, the following
characteristics of β-muricholic acid were shown: a low monomer solubility (13 μM), a high
equilibrium precipitation pH (7.92 for 30 mM solution), an apparent critical micellar
concentration of 4 mM, and a very low micellar capacity of the bile salt to dissolve the …