Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
B Wolozin, W Kellman, P Ruosseau… - Archives of …, 2000 - jamanetwork.com
Context Increasing evidence suggests that cholesterol plays a role in the pathophysiology of
Alzheimer disease (AD). For instance, an elevated serum cholesterol level has been shown
to be a risk factor for AD. Objective To determine whether patients taking 3-hydroxy-3-
methylglutaryl coenzyme A reductase inhibitors (statins), which are a group of medicines
that inhibit the synthesis of cholesterol, have a lower prevalence of probable AD. Design The
experiment uses a cross-sectional analysis comparing the prevalence of probable AD in 3 …
Alzheimer disease (AD). For instance, an elevated serum cholesterol level has been shown
to be a risk factor for AD. Objective To determine whether patients taking 3-hydroxy-3-
methylglutaryl coenzyme A reductase inhibitors (statins), which are a group of medicines
that inhibit the synthesis of cholesterol, have a lower prevalence of probable AD. Design The
experiment uses a cross-sectional analysis comparing the prevalence of probable AD in 3 …