Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use
KJ Moise Jr - American journal of obstetrics and gynecology, 1993 - Elsevier
OBJECTIVE: The objective of this study was to determine whether indomethacin is
associated with an increased incidence of constriction of the human fetal ductus arteriosus
with advancing gestational age. STUDY DESIGN: A retrospective analysis of fetal
echocardiograms performed in 44 patients with premature labor or hydramnios treated with
indomethacin (25 mg orally every 6 hours) was undertaken. Fisher's exact test, Kaplan-
Meier survival analysis, and log-rank techniques were used; a value of p< 0.05 was …
associated with an increased incidence of constriction of the human fetal ductus arteriosus
with advancing gestational age. STUDY DESIGN: A retrospective analysis of fetal
echocardiograms performed in 44 patients with premature labor or hydramnios treated with
indomethacin (25 mg orally every 6 hours) was undertaken. Fisher's exact test, Kaplan-
Meier survival analysis, and log-rank techniques were used; a value of p< 0.05 was …