The genome sequence of herpes simplex virus type 2

A Dolan, FE Jamieson, C Cunningham… - Journal of …, 1998 - Am Soc Microbiol
A Dolan, FE Jamieson, C Cunningham, BC Barnett, DJ McGeoch
Journal of virology, 1998Am Soc Microbiol
The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was
determined as 154,746 bp with a G+ C content of 70.4%. A total of 74 genes encoding
distinct proteins was identified; three of these were each present in two copies, within major
repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1,
and the HSV-2 sequence prompted several local revisions to the published HSV-1
sequence (DJ McGeoch, MA Dalrymple, AJ Davison, A. Dolan, MC Frame, D. McNab, LJ …
Abstract
The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was determined as 154,746 bp with a G+C content of 70.4%. A total of 74 genes encoding distinct proteins was identified; three of these were each present in two copies, within major repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1, and the HSV-2 sequence prompted several local revisions to the published HSV-1 sequence (D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor, J. Gen. Virol. 69:1531–1574, 1988). No compelling evidence for the existence of any additional protein-coding genes in HSV-2 was identified.
American Society for Microbiology