Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS
K Makhlouf, HL Weiner, SJ Khoury - Journal of neuroimmunology, 2001 - Elsevier
Interleukin (IL)-12 is a cytokine thought to play a major role in the pathogenesis of multiple
sclerosis (MS). We have previously shown that patients with progressive MS have a high
percentage of IL-12-producing monocytes in the blood compared to normal individuals. We
analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing
monocytes. We found that the increased IL-12 expression correlates with disability, as
measured by the Expanded Disability Status Scale (EDSS), and with disease activity …
sclerosis (MS). We have previously shown that patients with progressive MS have a high
percentage of IL-12-producing monocytes in the blood compared to normal individuals. We
analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing
monocytes. We found that the increased IL-12 expression correlates with disability, as
measured by the Expanded Disability Status Scale (EDSS), and with disease activity …