Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
JHW De Wilt, TLM ten Hagen, G De Boeck… - British journal of …, 2000 - nature.com
British journal of cancer, 2000•nature.com
Several possible mechanisms for the synergistic anti-tumour effects between tumour
necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been
presented. We found a significant sixfold increase in melphalan tumour tissue concentration
after ILP when TNF-α was added to the perfusate, which provides a straightforward
explanation for the observed synergism between melphalan and TNF-α in ILP.© 2000
Cancer Research Campaign
necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been
presented. We found a significant sixfold increase in melphalan tumour tissue concentration
after ILP when TNF-α was added to the perfusate, which provides a straightforward
explanation for the observed synergism between melphalan and TNF-α in ILP.© 2000
Cancer Research Campaign
Abstract
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP.© 2000 Cancer Research Campaign
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