Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α …

TP Salazar-Mather, JS Orange, CA Biron - The Journal of experimental …, 1998 - rupress.org
TP Salazar-Mather, JS Orange, CA Biron
The Journal of experimental medicine, 1998rupress.org
Natural killer (NK) cells mediate defense against early murine cytomegalovirus (MCMV)
infections in liver. The chemokine, macrophage inflammatory protein 1α (MIP-1α), can
promote inflammatory responses. Our studies evaluated contributions of NK cells to early
MCMV-induced liver inflammation and MIP-1α requirements for inflammation and delivery of
antiviral defenses. NK cells were shown to be responsible for focal inflammation, and to be
induced to migrate at high levels, in MCMV-infected livers. MIP-1α gene expression was …
Natural killer (NK) cells mediate defense against early murine cytomegalovirus (MCMV) infections in liver. The chemokine, macrophage inflammatory protein 1α (MIP-1α), can promote inflammatory responses. Our studies evaluated contributions of NK cells to early MCMV-induced liver inflammation and MIP-1α requirements for inflammation and delivery of antiviral defenses. NK cells were shown to be responsible for focal inflammation, and to be induced to migrate at high levels, in MCMV-infected livers. MIP-1α gene expression was elevated at coinciding times, and mice deficient in MIP-1α function were dramatically inhibited in both inflammatory and protective liver responses. The results precisely define MIP-1α–dependent steps required to achieve NK cell inflammation during, and mechanisms promoting defense against, viral infections in tissues.
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