Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
PA Antony, NP Restifo - Journal of Immunotherapy, 2002 - journals.lww.com
After years of banishment from mainstream immunology, the notion that one subset of T cells
can exert regulatory effects on other T lymphocytes is back in fashion. Recent work in
knockout and transgenic mice has begun to bring molecular definition to our understanding
of immunoregulatory CD4+ CD25+ T cells (Treg/Th3/Tr1). The identification of the
glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known
as TNFRSF18) expressed on T regulatory cells might afford new therapeutic opportunities …
can exert regulatory effects on other T lymphocytes is back in fashion. Recent work in
knockout and transgenic mice has begun to bring molecular definition to our understanding
of immunoregulatory CD4+ CD25+ T cells (Treg/Th3/Tr1). The identification of the
glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known
as TNFRSF18) expressed on T regulatory cells might afford new therapeutic opportunities …