HMG-CoA reductase inhibitors
DR Illingworth, JA Tobert - Advances in protein chemistry, 2001 - Elsevier
Publisher Summary This chapter focuses on the 3-Hydroxy-3-methylglutaryl-CoA (HMG-
CoA) reductase enzyme that is known as the rate limiting enzyme in the cholesterol
biosynthetic pathway. Today, HMG-CoA reductase inhibitors (statins) account for the large
majority of prescriptions for lipid-lowering drugs in most countries. In contrast to desmosterol
and other late-stage lipid-soluble intermediates, HMG is water-soluble, and there are
alternative metabolic pathways for its breakdown when HMG-CoA reductase is inhibited so …
CoA) reductase enzyme that is known as the rate limiting enzyme in the cholesterol
biosynthetic pathway. Today, HMG-CoA reductase inhibitors (statins) account for the large
majority of prescriptions for lipid-lowering drugs in most countries. In contrast to desmosterol
and other late-stage lipid-soluble intermediates, HMG is water-soluble, and there are
alternative metabolic pathways for its breakdown when HMG-CoA reductase is inhibited so …