Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.
J Sadoshima, L Jahn, T Takahashi, TJ Kulik… - Journal of Biological …, 1992 - ASBMB
Although it is a well-known fact that hemodynamic load is a major determinant of cardiac
muscle mass and its phenotype, little is known as to how mechanical load is converted into
intracellular signals of gene regulation. To address this question, we characterized the
stretch-induced adaptation of cultured neonatal cardiocytes grown on a stretchable
substrate in a serum-free medium. Static stretch (20%) of the cells was applied without cell
injury. Stretch caused hypertrophy in myocytes and hyperplasia in non-myocytes. Stretch …
muscle mass and its phenotype, little is known as to how mechanical load is converted into
intracellular signals of gene regulation. To address this question, we characterized the
stretch-induced adaptation of cultured neonatal cardiocytes grown on a stretchable
substrate in a serum-free medium. Static stretch (20%) of the cells was applied without cell
injury. Stretch caused hypertrophy in myocytes and hyperplasia in non-myocytes. Stretch …
