[HTML][HTML] Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin d3receptor: implications for allosteric influences on …
TL Towers, LP Freedman - Journal of Biological Chemistry, 1998 - ASBMB
The primary function of activated T lymphocytes is to produce various cytokines necessary to
elicit an immune response; these cytokines include interleukin-2 (IL-2), interleukin-4, and
granulocyte-macrophage colony-stimulating factor (GMCSF). Steroid hormones and vitamin
A and D 3 metabolites act to repress the expression of cytokines. 1, 25-Dihydroxyvitamin D 3
(1, 25-(OH) 2 D 3) down-modulates activated IL-2 expression at the level transcription,
through direct antagonism of the transactivating complex NFAT-1/AP-1 by the vitamin D 3 …
elicit an immune response; these cytokines include interleukin-2 (IL-2), interleukin-4, and
granulocyte-macrophage colony-stimulating factor (GMCSF). Steroid hormones and vitamin
A and D 3 metabolites act to repress the expression of cytokines. 1, 25-Dihydroxyvitamin D 3
(1, 25-(OH) 2 D 3) down-modulates activated IL-2 expression at the level transcription,
through direct antagonism of the transactivating complex NFAT-1/AP-1 by the vitamin D 3 …