[HTML][HTML] Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel
WA Chutkow, JC Makielski, DJ Nelson… - Journal of Biological …, 1999 - ASBMB
ATP-sensitive potassium channels (K ATP) are implicated in a diverse array of physiological
functions. Previous work has shown that alternative usage of exons 14, 39, and 40 of the
muscle-specific K ATP channel regulatory subunit, sur2, occurs in tissue-specific patterns.
Here, we show that exon 17 of the first nucleotide binding fold of sur2 is also alternatively
spliced. RNase protection demonstrates that SUR2 (Δ17) predominates in skeletal muscle
and gut and is also expressed in bladder, fat, heart, lung, liver, and kidney. Polymerase …
functions. Previous work has shown that alternative usage of exons 14, 39, and 40 of the
muscle-specific K ATP channel regulatory subunit, sur2, occurs in tissue-specific patterns.
Here, we show that exon 17 of the first nucleotide binding fold of sur2 is also alternatively
spliced. RNase protection demonstrates that SUR2 (Δ17) predominates in skeletal muscle
and gut and is also expressed in bladder, fat, heart, lung, liver, and kidney. Polymerase …