Suppressive effects of visceral tumor on the generation of antitumor T cells for adoptive immunotherapy
VK Sondak, PD Wagner, S Shu, AE Chang - Archives of Surgery, 1991 - jamanetwork.com
• Antitumor reactive cells can be generated from lymphoid organs of mice bearing
subcutaneous (SC), but not liver or lung, tumors by in vitro sensitization with irradiated tumor
and interleukin 2. To examine whether visceral tumors mediated tumorinduced suppression,
in vitro sensitization cells were generated from mice bearing SC tumors with and without
concomitant liver or lung tumors. Antitumor efficacy of these cells was assessed in adoptive
immunotherapy experiments. The presence of visceral tumors suppressed the ability to …
subcutaneous (SC), but not liver or lung, tumors by in vitro sensitization with irradiated tumor
and interleukin 2. To examine whether visceral tumors mediated tumorinduced suppression,
in vitro sensitization cells were generated from mice bearing SC tumors with and without
concomitant liver or lung tumors. Antitumor efficacy of these cells was assessed in adoptive
immunotherapy experiments. The presence of visceral tumors suppressed the ability to …