[HTML][HTML] An Abd-B class HOX· PBX recognition sequence is required for expression from the mouse Ren-1c gene
L Pan, Y Xie, TA Black, CA Jones, SC Pruitt… - Journal of Biological …, 2001 - ASBMB
Expression from the mouseRen-1 c gene in As4. 1 cells is dependent on a proximal
promoter element (PPE) located at approximately− 60 and a 241-base pair enhancer region
located at− 2625 relative to the transcription start site. The PPE (TAATAAATCAA) is identical
to a consensus HOX· PBX binding sequence. Further, PBX1b has been shown to be a
component of a PPE-specific binding complex present in nuclear extracts from As4. 1 cells.
The binding affinities of different paralog HOX members to the PPE were examined in the …
promoter element (PPE) located at approximately− 60 and a 241-base pair enhancer region
located at− 2625 relative to the transcription start site. The PPE (TAATAAATCAA) is identical
to a consensus HOX· PBX binding sequence. Further, PBX1b has been shown to be a
component of a PPE-specific binding complex present in nuclear extracts from As4. 1 cells.
The binding affinities of different paralog HOX members to the PPE were examined in the …