[HTML][HTML] Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression
L Pan, TA Black, Q Shi, CA Jones, N Petrovic… - Journal of Biological …, 2001 - ASBMB
Mouse As4. 1 cells, obtained after transgene-targeted oncogenesis to induce neoplasia in
renal renin expressing cells, express high levels of renin mRNA from their endogenous Ren-
1 c gene. We have previously identified a 242-base pair enhancer (coordinates− 2866 to−
2625 relative to the CAP site) upstream of the mouseRen-1 c gene. This enhancer, in
combination with the proximal promoter (− 117 to+ 6), activates transcription nearly 2 orders
of magnitude in an orientation independent fashion. To further delimit sequences necessary …
renal renin expressing cells, express high levels of renin mRNA from their endogenous Ren-
1 c gene. We have previously identified a 242-base pair enhancer (coordinates− 2866 to−
2625 relative to the CAP site) upstream of the mouseRen-1 c gene. This enhancer, in
combination with the proximal promoter (− 117 to+ 6), activates transcription nearly 2 orders
of magnitude in an orientation independent fashion. To further delimit sequences necessary …