The spindle assembly checkpoint
AD Rudner, AW Murray - Current opinion in cell biology, 1996 - Elsevier
AD Rudner, AW Murray
Current opinion in cell biology, 1996•ElsevierThe spindle assembly checkpoint monitors proper chromosome attachment to spindle
microtubules and is conserved from yeast to humans. Checkpoint components reside on
kinetochores of chromosomes and show changes in phosphorylation and localization as
cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by
inhibitory phosphorylation of Cdc2.
microtubules and is conserved from yeast to humans. Checkpoint components reside on
kinetochores of chromosomes and show changes in phosphorylation and localization as
cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by
inhibitory phosphorylation of Cdc2.
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2.
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