[HTML][HTML] Comparison of paclitaxel-, 5-fluoro-2′-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis: Evidence for EGF-induced anoikis
TJ Kottke, AL Blajeski, LM Martins, PW Mesner… - Journal of Biological …, 1999 - ASBMB
Epidermal growth factor (EGF), a hormone that stimulates proliferation of many cell types,
induces apoptosis in some cell lines that overexpress the EGF receptor. To evaluate the
mechanism of EGF-induced apoptosis, MDA-MB-468 breast cancer cells were examined by
microscopy, flow cytometry, immunoblotting, enzyme assays, and affinity labeling after
treatment with EGF, paclitaxel, or 5-fluoro-2′-deoxyuridine (5FUdR). Apoptosis induced by
all three agents was accompanied by activation of caspases-3,-6, and-7, as indicated by …
induces apoptosis in some cell lines that overexpress the EGF receptor. To evaluate the
mechanism of EGF-induced apoptosis, MDA-MB-468 breast cancer cells were examined by
microscopy, flow cytometry, immunoblotting, enzyme assays, and affinity labeling after
treatment with EGF, paclitaxel, or 5-fluoro-2′-deoxyuridine (5FUdR). Apoptosis induced by
all three agents was accompanied by activation of caspases-3,-6, and-7, as indicated by …