Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report
E Hodak, G Yosipovitch, M David, A Ingber… - Journal of the American …, 1998 - Elsevier
Background: Low-dose heparin devoid of anticoagulant activity inhibits T-lymphocyte
heparanase activity, which is crucial in T-cell migration to target tissues. Objective: The
purpose of this study was to assess the efficacy of low-dose enoxaparin (Clexane), a low-
molecular-weight heparin, as monotherapy in lichen planus. Methods: Included in the study
were 10 patients with widespread histopathologically proven lichen planus (LP) associated
with intense pruritus of several months' duration. Patients were given 3 mg enoxaparin …
heparanase activity, which is crucial in T-cell migration to target tissues. Objective: The
purpose of this study was to assess the efficacy of low-dose enoxaparin (Clexane), a low-
molecular-weight heparin, as monotherapy in lichen planus. Methods: Included in the study
were 10 patients with widespread histopathologically proven lichen planus (LP) associated
with intense pruritus of several months' duration. Patients were given 3 mg enoxaparin …