Synthesis of sulfated trisaccharide ligands for the selectins
WJ Sanders, DD Manning, KM Koeller, LL Kiessling - Tetrahedron, 1997 - Elsevier
In a directed effort to elucidate the molecular factors responsible for selectin-mediated cell
adhesion events as a basis for the generation of potent and specific inhibitors of these
processes, we have synthesized a variety of sulfated analogs of the trisaccharide
recognition epitopes Lewis a [Lea: Galβ1→ 3 (Fucα1→ 4) GlcNAc] and Lewis x [Lex:
Galβ1→ 4 (Fucα1→ 3) GlcNAc]. Our divergent synthetic route allows for the synthesis of
gram quantities of these sulfated trisaccharides from common intermediates in 10–20 …
adhesion events as a basis for the generation of potent and specific inhibitors of these
processes, we have synthesized a variety of sulfated analogs of the trisaccharide
recognition epitopes Lewis a [Lea: Galβ1→ 3 (Fucα1→ 4) GlcNAc] and Lewis x [Lex:
Galβ1→ 4 (Fucα1→ 3) GlcNAc]. Our divergent synthetic route allows for the synthesis of
gram quantities of these sulfated trisaccharides from common intermediates in 10–20 …