[HTML][HTML] Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups
K Norgard-Sumnicht, A Varki - Journal of Biological Chemistry, 1995 - ASBMB
We earlier reported calcium-dependent, heparin-like L-selectin ligands in cultured bovine
endothelial cells (Norgard-Sumnicht, KE, Varki, NM, and Varki, A.(1993) Science 261,480-
483). Here we show that these are heparan sulfate proteoglycans (HSPGs) associated
either with the cultured cells or secreted into the medium and extracellular matrix. Activation
of the endothelial cells with bacterial lipopolysaccharide (LPS) does not markedly alter the
amount or distribution of this material. A major portion of the glycosaminoglycan (GAG) …
endothelial cells (Norgard-Sumnicht, KE, Varki, NM, and Varki, A.(1993) Science 261,480-
483). Here we show that these are heparan sulfate proteoglycans (HSPGs) associated
either with the cultured cells or secreted into the medium and extracellular matrix. Activation
of the endothelial cells with bacterial lipopolysaccharide (LPS) does not markedly alter the
amount or distribution of this material. A major portion of the glycosaminoglycan (GAG) …