[HTML][HTML] The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
Cell, 1996•cell.com
We examined the ability of chemokine receptors and related G protein–coupled receptors to
facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with
CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be
infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and
binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3
and CCR5 on the target cell depended upon the sequence of the third variable (V3) region …
facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with
CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be
infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and
binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3
and CCR5 on the target cell depended upon the sequence of the third variable (V3) region …
Abstract
We examined the ability of chemokine receptors and related G protein–coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein. The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and β-chemokine inhibition of primary HIV-1 isolates.
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