TGF-β in the cardiovascular system: molecular mechanisms of a context-specific growth factor
JN Topper - Trends in Cardiovascular Medicine, 2000 - Elsevier
Transforming growth factor beta-1 is the prototypical member of a class of growth factors
whose actions have been strongly implicated in a number of pathophysiologic processes
including chronic vascular diseases such as atherosclerosis and hypertension. One of the
hallmarks of this class of growth factors is the diverse nature of their actions; a characteristic
that is thought to arise from the fact that the effects of these factors are very dependent upon
the particular cellular context in which they operate. There has been substantial progress in …
whose actions have been strongly implicated in a number of pathophysiologic processes
including chronic vascular diseases such as atherosclerosis and hypertension. One of the
hallmarks of this class of growth factors is the diverse nature of their actions; a characteristic
that is thought to arise from the fact that the effects of these factors are very dependent upon
the particular cellular context in which they operate. There has been substantial progress in …