Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity
MS Pepper - Cytokine & growth factor reviews, 1997 - Elsevier
Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-β1)
and its receptors (TGF-βRs I and II as well as endoglin) in embryonic vascular assembly and
in the establishment and maintenance of vessel wall integrity. The purpose of this review is
threefold: first, to reassess previous studies on TGF-β and endothelium in the light of these
recent findings; second, to describe some of the well-established as well as controversial
issues concerning TGF-β and its regulatory role in angiogenesis; and third, to explore the …
and its receptors (TGF-βRs I and II as well as endoglin) in embryonic vascular assembly and
in the establishment and maintenance of vessel wall integrity. The purpose of this review is
threefold: first, to reassess previous studies on TGF-β and endothelium in the light of these
recent findings; second, to describe some of the well-established as well as controversial
issues concerning TGF-β and its regulatory role in angiogenesis; and third, to explore the …