Role of hypothalamic neuropeptide Y in feeding and obesity
DR Gehlert - Neuropeptides, 1999 - Elsevier
The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat
brain. When administered into the brain, NPY produces a variety of physiological actions
including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic
NPY have been reported after food deprivation and in genetically obese rodents. NPY is
believed to produce its actions through a portfolio of G-protein coupled receptors, Y1, Y2, Y4
and Y5. Studies using peptide analogs, receptor knockout animals and specific receptor …
brain. When administered into the brain, NPY produces a variety of physiological actions
including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic
NPY have been reported after food deprivation and in genetically obese rodents. NPY is
believed to produce its actions through a portfolio of G-protein coupled receptors, Y1, Y2, Y4
and Y5. Studies using peptide analogs, receptor knockout animals and specific receptor …