[HTML][HTML] Defective urinary concentrating ability due to a complete deficiency of aquaporin-1

LS King, M Choi, PC Fernandez… - New England Journal …, 2001 - Mass Medical Soc
LS King, M Choi, PC Fernandez, JP Cartron, P Agre
New England Journal of Medicine, 2001Mass Medical Soc
Aquaporin-1, the archetypal water-channel protein, 1 was initially identified in red cells and
renal proximal tubular epithelium. 2 The gene for aquaporin-1 (AQP1) on chromosome 7
colocalizes with the Colton blood-group antigen, 3, 4 and the Colton blood-group antigen
polymorphism was identified as a substitution of a single amino acid in an extracellular
domain of aquaporin-1.5 The International Blood Group Reference Laboratory has
confirmed the existence of only six kindreds who lack the Colton blood group. Members of …
Aquaporin-1, the archetypal water-channel protein,1 was initially identified in red cells and renal proximal tubular epithelium.2 The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group antigen,3,4 and the Colton blood-group antigen polymorphism was identified as a substitution of a single amino acid in an extracellular domain of aquaporin-1.5 The International Blood Group Reference Laboratory has confirmed the existence of only six kindreds who lack the Colton blood group. Members of three of these kindreds were found to be homozygous for different mutations in the AQP1 gene, and their red-cell membranes had a complete . . .
The New England Journal Of Medicine