[HTML][HTML] Water channel properties of major intrinsic protein of lens

SM Mulders, GM Preston, PMT Deen… - Journal of Biological …, 1995 - ASBMB
The functions of major intrinsic protein (MIP) of lens are still unresolved; however the
sequence homology with channel-forming integral membrane protein (CHIP) and other
Aquaporins suggests that MIP is a water channel. Immunolocalizations confirmed that
Xenopus oocytes injected with bovine MIP cRNA express the protein and target it to the
plasma membrane. Control oocytes or oocytes expressing MIP or CHIP exhibited small,
equivalent membrane currents that could be reversibly increased by osmotic swelling. When …