[HTML][HTML] Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine
DE Greenwalt, RH Lipsky, CF Ockenhouse, H Ikeda… - Blood, 1992 - Elsevier
DE Greenwalt, RH Lipsky, CF Ockenhouse, H Ikeda, NN Tandon, GA Jamieson
Blood, 1992•ElsevierWHEN IT WAS first identified, platelet glycoprotein GPIV was shown to have a remarkable
resistance to protease digestion. 1., 2. It was subsequently shown to be relatively increased
in myeloproliferative disorders. 3., 4. More recently, there has been an explosion of
information which has shown that GPIV is identical with the leukocyte differentiation antigen
CD36, which occurs in a wide range of cells and tissues, and that it plays major roles in
adhesion phenomena, signal transduction, and hematopathology. Furthermore, it, together …
resistance to protease digestion. 1., 2. It was subsequently shown to be relatively increased
in myeloproliferative disorders. 3., 4. More recently, there has been an explosion of
information which has shown that GPIV is identical with the leukocyte differentiation antigen
CD36, which occurs in a wide range of cells and tissues, and that it plays major roles in
adhesion phenomena, signal transduction, and hematopathology. Furthermore, it, together …
WHEN IT WAS first identified, platelet glycoprotein GPIV was shown to have a remarkable resistance to protease digestion. 1., 2. It was subsequently shown to be relatively increased in myeloproliferative disorders. 3., 4. More recently, there has been an explosion of information which has shown that GPIV is identical with the leukocyte differentiation antigen CD36, which occurs in a wide range of cells and tissues, and that it plays major roles in adhesion phenomena, signal transduction, and hematopathology. Furthermore, it, together with the CD36-related protein LIMP II, may be a member of a hitherto-unrecognized family of receptor molecules.
The purpose of the present review is to summarize the current status of knowledge of CD36, which is the generic term we will use in this review for this important glycoprotein. CD36 has also been termed GP88, 5 GPIIIb, 6 and PAS IV. 7
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