[HTML][HTML] Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase
ML McCormick, JP Gaut, TS Lin, BE Britigan… - Journal of Biological …, 1998 - ASBMB
Phagocytes secrete the heme protein myeloperoxidase, which is present and active in
human atherosclerotic tissue. These cells also generate hydrogen peroxide (H 2 O 2),
thereby allowing myeloperoxidase to generate a range of oxidizing intermediates and stable
end products. When this system acts on l-tyrosine in vitro, it forms o, o′-dityrosine, which is
enriched in atherosclerotic lesions. Myeloperoxidase, therefore, may oxidize artery wall
proteins in vivo, cross-linking theirl-tyrosine residues. In these studies, we used electron …
human atherosclerotic tissue. These cells also generate hydrogen peroxide (H 2 O 2),
thereby allowing myeloperoxidase to generate a range of oxidizing intermediates and stable
end products. When this system acts on l-tyrosine in vitro, it forms o, o′-dityrosine, which is
enriched in atherosclerotic lesions. Myeloperoxidase, therefore, may oxidize artery wall
proteins in vivo, cross-linking theirl-tyrosine residues. In these studies, we used electron …