Type I interferons and the Th1/Th2 paradigm
F Sinigaglia, D D'Ambrosio, L Rogge - Developmental & Comparative …, 1999 - Elsevier
During the past year significant advances have been made in our understanding of the
factors contributing to the differentiation of CD4+ T helper cell subsets. These have been
driven, in part, by the realization that cytokines from the innate immune response, such as
interleukin-12 (IL-12) and interferons (IFNs), play a critical role in T cell subset differentiation.
This review covers some of the most recent data concerning the divergent role that IFNs
have in the differentiation of human versus mouse T helper cell subsets. In this review we …
factors contributing to the differentiation of CD4+ T helper cell subsets. These have been
driven, in part, by the realization that cytokines from the innate immune response, such as
interleukin-12 (IL-12) and interferons (IFNs), play a critical role in T cell subset differentiation.
This review covers some of the most recent data concerning the divergent role that IFNs
have in the differentiation of human versus mouse T helper cell subsets. In this review we …