Insulin-like growth factors
D Le Roith - New England Journal of Medicine, 1997 - Mass Medical Soc
D Le Roith
New England Journal of Medicine, 1997•Mass Medical SocThe insulin-like growth factors (IGFs) participate in the growth and function of almost every
organ in the body. 1 Because of the wide range of their biologic effects and their therapeutic
potential in a variety of clinical disorders, the IGFs have become the focus of research by an
increasing number of investigators. 2–4 The object of this seminar is to review the clinical
aspects of the IGFs, including their potential therapeutic value, and to discuss briefly their
structure, synthesis, regulation, and physiologic role. Basic Biochemistry and Physiologic …
organ in the body. 1 Because of the wide range of their biologic effects and their therapeutic
potential in a variety of clinical disorders, the IGFs have become the focus of research by an
increasing number of investigators. 2–4 The object of this seminar is to review the clinical
aspects of the IGFs, including their potential therapeutic value, and to discuss briefly their
structure, synthesis, regulation, and physiologic role. Basic Biochemistry and Physiologic …
The insulin-like growth factors (IGFs) participate in the growth and function of almost every organ in the body.1 Because of the wide range of their biologic effects and their therapeutic potential in a variety of clinical disorders, the IGFs have become the focus of research by an increasing number of investigators.2–4 The object of this seminar is to review the clinical aspects of the IGFs, including their potential therapeutic value, and to discuss briefly their structure, synthesis, regulation, and physiologic role.
Basic Biochemistry and Physiologic Functions
Structure and Synthesis
The three peptide hormones, or growth factors, in the IGF . . .
The New England Journal Of Medicine