Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways
The leukemia inhibitory factor/interleukin 6 (LIF/IL6) family of cytokines promotes cell type-
specific pleiotropic effects by engaging multimeric receptor complexes that share the
common affinity converter/signal transducing subunit gp130. While the maintenance of
embryonic stem (ES) cell self-renewal is an activity unique to this family of cytokines, the
intracellular signaling events mediated by gp130 remain largely unknown. Here we show a
rapid and transient increase in the specific activity of the Src-related kinase Hck as well as of …
specific pleiotropic effects by engaging multimeric receptor complexes that share the
common affinity converter/signal transducing subunit gp130. While the maintenance of
embryonic stem (ES) cell self-renewal is an activity unique to this family of cytokines, the
intracellular signaling events mediated by gp130 remain largely unknown. Here we show a
rapid and transient increase in the specific activity of the Src-related kinase Hck as well as of …
