1α,25(OH)₂vitamin-D₃, [1α,25(OH)₂D₃] is a potent steroid hormone that produces a wide array of biologic effects in a variety of target tissues within the body through its ability to modulate gene transcription of specific target genes. Evidence for transcription regulation of a specific gene typically includes 1α,25(OH)₂D₃-induced modulation in mRNA levels. Additionally, evidence may include measurements of transcription and or the presence of a vitamin D response element within the promoter region of the gene. To date, over 50 genes have been reported to be transcriptionally regulated by 1α,25(OH)₂D₃- We present a current list of these genes and the evidence supporting their inclusion on the list.