Immunosuppressive actions of 1, 25-dihydroxyvitamin D3: preferential inhibition of Th1 functions
JM Lemire, DC Archer, L Beck, HL Spiegelberg - The Journal of nutrition, 1995 - Elsevier
Dihydroxyvitamin D 3 [1, 25-(OH) 2-D 3] is known to be an immunosuppressive hormone.
This review primarily deals with in vitro and in vivo effects of 1, 25-(OH) 2-D 3 and analogue,
1, 25-dihydroxy-16ene-vitamin D 3 [1, 25-(OH) 2-16ene-D 3], on T helper subsets type 1 (Th
1) or type 2 (Th 2) that have distinctive functional characteristics in humans. Th 1 secrete
interferon (IFN-γ), interleukin (IL-2) and induce B cells to produce immunoglobulin IgG 2a
while Th 2 secrete IL-4, IL-10 and induce the production of IgG 1 and IgE by B cells. The …
This review primarily deals with in vitro and in vivo effects of 1, 25-(OH) 2-D 3 and analogue,
1, 25-dihydroxy-16ene-vitamin D 3 [1, 25-(OH) 2-16ene-D 3], on T helper subsets type 1 (Th
1) or type 2 (Th 2) that have distinctive functional characteristics in humans. Th 1 secrete
interferon (IFN-γ), interleukin (IL-2) and induce B cells to produce immunoglobulin IgG 2a
while Th 2 secrete IL-4, IL-10 and induce the production of IgG 1 and IgE by B cells. The …