Differential expression of transforming growth factor-β receptors I and II and activation of Smad 3 in keloid fibroblasts
GS Chin, W Liu, Z Peled, TY Lee… - Plastic and …, 2001 - journals.lww.com
GS Chin, W Liu, Z Peled, TY Lee, DS Steinbrech, M Hsu, MT Longaker
Plastic and reconstructive surgery, 2001•journals.lww.comKeloids represent a dysregulated response to cutaneous wounding that results in an
excessive deposition of extracellular matrix, especially collagen. However, the molecular
mechanisms regulating this pathologic collagen deposition still remain to be elucidated. A
previous study by this group demonstrated that transforming growth factor (TGF)-[beta] 1 and-
[beta] 2 ligands were expressed at greater levels in keloid fibroblasts when compared with
normal human dermal fibroblasts (NHDFs), suggesting that TGF-[beta] may play a fibrosis …
excessive deposition of extracellular matrix, especially collagen. However, the molecular
mechanisms regulating this pathologic collagen deposition still remain to be elucidated. A
previous study by this group demonstrated that transforming growth factor (TGF)-[beta] 1 and-
[beta] 2 ligands were expressed at greater levels in keloid fibroblasts when compared with
normal human dermal fibroblasts (NHDFs), suggesting that TGF-[beta] may play a fibrosis …
Abstract
Keloids represent a dysregulated response to cutaneous wounding that results in an excessive deposition of extracellular matrix, especially collagen. However, the molecular mechanisms regulating this pathologic collagen deposition still remain to be elucidated. A previous study by this group demonstrated that transforming growth factor (TGF)-[beta] 1 and-[beta] 2 ligands were expressed at greater levels in keloid fibroblasts when compared with normal human dermal fibroblasts (NHDFs), suggesting that TGF-[beta] may play a fibrosis-promoting role in keloid pathogenesis.
Lippincott Williams & Wilkins